In an attempt to stop the Extremis-powered terrorist Mallen, Tony Stark was fatally injured by the criminal.[3] Seeing no other option, Tony convinced Extremis co-developer Maya Hansen to inject him a dose of Extremis to heal his injuries. Additionally, Stark had been working on an experimental Iron Man Armour that was tougher and lighter than his then-current unit. However, he couldn’t miniaturize the suit’s control systems and other vital elements. In order to overcome this obstacle, the Extremis dose was modified so that the crucial under-sheath of the Iron Man suit was supercompressed and stored in the hollows of Tony’s bones. The undersheath became directly wired to Tony’s brain, which allowed him to control the new Iron Man Armour with thought and even interface with other technologies.
During the Skrulls invasion on Earth, Tony’s body was infected with an alien virus that shut down his Extremis enhancements and prevented him from making proper use of this armour. Many years later, after waking up from a coma, Tony returned to using the Extremis Armour, albeit a version most likely adapted to his now-ordinary biology.